Top will be meeting bottom in the standings with the visitors already as many as 14 points adrift of a relegation playoff place.
Having recently put together a 13-match undefeated streak, it appeared that Shamrock Rovers may eventually canter to the league title, that period also including a run of nine wins in 10 outings.
However, the defending champions have realised that complacency cannot set in, with defeats to Drogheda United and Cork City following in quick succession.
The Hoops have since responded with victories and clean sheets against Dundalk and Sligo Rovers, yet they now sit just four points clear of the chasing pack.
Fortunately for Stephen Bradley's side, their nearest rivals have struggled for consistency, and the perception is that they effectively have a free pass to at least maintain their lead in first position.
In the previous two meetings with UCD during the 2023 campaign, Shamrock have recorded wins in each fixture, scored five goals and kept two clean sheets in the process.
There was a period in April when UCD looked like they were building some momentum, accumulating five points from as many matches to give themselves some hope.
Since then, Andrew Myler's side have lost seven games in succession, shipping as many as 20 goals during that period to leave relegation already a near certainty barring a miracle revival.
With 17 encounters still remaining, it would be unfair to completely write off UCD, yet this is a side who have netted just 11 times in 20 contests.
While at least three goals have been conceded in their last four fixtures, the solitary positive is that one strike has been netted at the other end.
Bradley will be torn between attempting to show a ruthless streak against the division's minnows and potentially resting a number of players.
That said, he was able to do that during the second half at Sligo, and Shamrock players such as Sean Kavanagh and Darragh Nugent may be given opportunities in a five-man midfield over changes being made in attack.
UCD were forced into an early change last time out when Ciaran Behan was withdrawn through injury after just eight minutes.
While Danu Kinsella Bishop, a forward rather than central midfielder, was introduced on that occasion, Dara Keane could be recalled instead in what may prove to be the only change unless Myler tinkers with his backline.
Shamrock Rovers possible starting lineup:
Pohls; Lopes, Cleary, Grace; Gannon, Poom, Byrne, Nugent, Ferguson; Gaffney, Kenny
University College Dublin possible starting lineup:
Moore; Gallagher, O'Brien, Wells, Keaney, Osam; Nolan, Barr, Keane, Norris; Doyle
We say: Shamrock Rovers 4-0 University College Dublin
Although Shamrock have slipped up on a couple of occasions of late, this should be a breeze for the home side. The visitors have not conceded fewer than three goals in their recent matches, and we expect that unwanted streak to continue here.
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